The relationship between the anterior pituitary gland and the pancreas in tail regeneration of the adult newt.

Histological examination of the amputated tails of 17 hypophysectomized newts revealed abnormal and extremely retarded regenerates; four of them exhibited total inhibition of regeneration. Thus, under the conditions of hypophysectomy, normal tail regeneration does not ensue in the adult Diemictylus viridescens. Also, hypophysectomy adversely affects the normal histology of both the endocrine and exocrine parts of the pancreas, as observed by the atrophy of the gland in all hypophysectomized cases. Presumably, the normal function of the gland was altered. This relationship between hypophysectomy and the atrophic pancreas suggests a possible involvement of the pancreas in tail and limb regeneration in the adult newt.